Figure 6 | Scientific Reports

Figure 6

From: Tumor microenvironment heterogeneity in bladder cancer identifies biologically distinct subtypes predicting prognosis and anti-PD-L1 responses

Figure 6

Mutation among three subtypes. (A) Waterfall diagram of three subtypes in TCGA-BLCA cohort shows top 20 mutated genes among three subtypes. Mutations in TP53 (B) and RB1 (C) were more common in C2, whereas those of PIK3CA (D) and FGFR3 (E) were more prevalent in the C1 and C3 subtypes, respectively. Differences among tumor mutation burdens in three subtypes in TCGA-BLCA (F) and IMvigor210 (G) cohorts. C1 subtype has highest burden of tumor mutations among three subtypes in both cohorts.

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