Figure 8 | Scientific Reports

Figure 8

From: Tumor microenvironment heterogeneity in bladder cancer identifies biologically distinct subtypes predicting prognosis and anti-PD-L1 responses

Figure 8

Validation of signature to predict anti-PD-L1 response. (A) Risk scores was negatively correlated with tumor mutation burden. (B) ROC curves show the abilities of risk scores (AUC = 0.74), PD-L1 mRNA (AUC = 0.567), and PD-L1 IC scores (AUC = 0.618) to predict anti-PD-L1 response. (C) Risk scores were higher among non-responders than responders. (D) Patients with more abundant PD-L1 ICs had better response rates. (E) Response rates in the high vs. low risk groups (11% vs. 35%). (F) Immunohistochemically determined PD-L1 expression in immune cells (ICs) in high- and low-risk groups.

Back to article page