Figure 3
Selinexor (Sel) is effective in restoring drug-induced cytotoxicity. CLL samples were categorized as drug-sensitive or drug-resistant if their normalized cell viability after the specific drug treatment was ≤ or > 0.5, respectively. In the CLL samples characterized by in vitro resistance to bendamustine (Ben) (a,b), fludarabine (F-ara-A) (c,d) or idelalisib (Ide) (e,f), the addition of selinexor significantly increased drug-induced cytotoxicity at the majority of tested concentrations. Box plots represent median value and 25–75% percentiles for 72-h viability, whiskers represent minimum and maximum values for each group; each point represents a single sample. Asterisks indicate the combinations determining a significant reduction in cell viability compared to both single agents, at the corresponding concentration. ****p < 0.0001, ***p < 0.001, **p < 0.01 and *p < 0.05.
