Figure 1

Protein–protein interaction network analysis with blue and red circles representing downregulated and upregulated proteins, respectively, for the lifestyle versus control group (log2 fold difference). The size of the circle represents the t-test q-value (larger circles have q-values closer to 0, and smaller circles closer to 0.05). The gray areas represent proteins downregulated in immune response activities and upregulated for lipoprotein processing. Other significant reactome pathways that differed between the lifestyle and control groups are indicated. This graph was developed with Cytoscape: Institute for Systems Biology. Cytoscape. 2023. Available from: https://www.cytoscape.org.