Table 2 Descriptions and names of proteins that were lower (n = 18) and higher (n = 21) in the lifestyle versus control group (all 39 proteins, FDR correction, q < 0.05).
Group fold difference (log2) | Protein ID# | Gene | Protein names and short descriptions of functions |
|---|---|---|---|
Proteins that were lower in the lifestyle versus control group | |||
− 0.5919 | *P02743 | APCS | Serum amyloid P-component; An acute phase protein involved in inflammation via complement-dependent pathways |
− 0.441927 | P00738 | HP | Haptoglobin; Captures hemoglobin; acts as an antimicrobial and antioxidant and modulates the acute phase response |
− 0.397979 | *P00751 | CFB | Complement factor B; Part of the alternate pathway of the complement system |
− 0.362202 | *P00740 | F9 | Coagulation factor IX; Participates in the intrinsic pathway of blood coagulation |
− 0.327764 | P0C0L5 | C4B | Complement C4-B; Non-enzymatic component of C3 and C5 convertases; propagates the complement pathway |
− 0.303047 | P02763 | ORM1 | Alpha-1-acid glycoprotein 1; Transport protein; modulates immune activity during the acute-phase reaction |
− 0.300494 | *P01024 | C3 | Complement C3; Plays a central role in the activation of the complement system |
− 0.286746 | P05156 | CFI | Complement factor I; Cleaves alpha-chains of C4b, C3b with cofactors C4-binding protein and factor H |
− 0.286538 | *P68104 | EEF1A1 | Elongation factor 1-alpha 1; Role in the positive regulation of interferon gamma transcription in T-helper 1 cells |
− 0.282922 | *P19652 | ORM2 | Alpha-1-acid glycoprotein 2; Transport protein; modulates immune activity during the acute-phase reaction |
− 0.275192 | P08603 | CFH | Complement factor H; Functions as a cofactor in the inactivation of C3b |
− 0.27405 | P08311 | CTSG | Cathepsin G; Cleaves complement C3 and has antibacterial activity |
− 0.264261 | *P43652 | AFM | Afamin; Vitamin E binding protein |
− 0.258812 | P04004 | VTN | Vitronectin; Cell adhesion factor for inhibition of the terminal cytolytic complement pathway |
− 0.244408 | P02751 | FN1 | Fibronectin 1; Involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape |
− 0.229351 | P05546 | SERPIND1 | Heparin cofactor 2; Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate |
− 0.202753 | P36955 | SERPINF1 | Pigment epithelium-derived factor; Neurotrophic protein; induces neuronal differentiation; inhibits angiogenesis |
− 0.132368 | P01031 | C5 | Complement C5; Activation initiates the spontaneous assembly of the membrane attack complex |
Proteins that were higher in the lifestyle versus control group | |||
0.105871 | *Q15435 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7; Regulatory subunit of protein phosphatase 1, and is required for completion of the mitotic cycle |
0.129966 | Q86X55 | CARM1 | Histone-arginine methyltransferase CARM1; Methylates guanidino nitrogens of arginyl residues and acts on histones and the regulation of gene expression |
0.155758 | P02647 | APOA1 | Apolipoprotein A-I; The major protein component of high density lipoprotein (HDL) in plasma. Participates in the reverse transport of cholesterol from tissues to the liver |
0.160256 | P06396 | GSN | Gelsolin; Actin-modulating protein that is involved in filament assembly; influences cell processes including cells of the immune system |
0.166127 | P14550 | AKR1A1 | Alcohol dehydrogenase [NADP( +)]; Catalyzes the NADPH-dependent reduction of aldehydes to alcohols |
0.175456 | P01008 | SERPINC1 | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade |
0.188729 | P08397 | HMBS | Porphobilinogen deaminase; Produces an enzyme involved in heme production |
0.194536 | O94903 | PLPBP | Pyridoxal phosphate homeostasis protein; Intracellular regulation of pyridoxal 5′-phosphate (PLP), vitamin B6 |
0.202922 | *P02766 | TTR | Thyroid hormone-binding protein; Transports thyroxine from the bloodstream to the brain |
0.217191 | *P37840 | SNCA | Alpha-synuclein; Involved in the regulation of dopamine release and transport |
0.228831 | *P05089 | ARG1 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine |
0.244906 | *P01023 | A2M | Alpha-2-macroglobulin; Inhibits all four classes of proteinases by a unique 'trapping' mechanism. Inhibits inflammatory cytokines and inflammatory cascades |
0.26744 | *P02768 | ALB | Serum albumin; Main function is the regulation of the colloidal osmotic pressure of blood; acts as a carrier protein for many molecules |
0.267692 | O95445 | APOM | Apolipoprotein M; Involved with lipid transport |
0.269348 | P02654 | APOC1 | Apolipoprotein C-I; Plays a central role in HDL and very low density lipoprotein (VLDL) metabolism |
0.273906 | *P54252 | ATXN3 | Ataxin-3; Protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis, and degradation |
0.279698 | P05090 | APOD | Apolipoprotein D; Encodes a component of HDL; involved in lipoprotein metabolism and the transport and binding of bilin (e.g., bilirubin) |
0.301995 | *P35858 | IGFALS | Insulin-like growth factor-binding protein complex acid labile subunit; Binds insulin-like growth factors, increasing their half-life; influences protein complexes, cell adhesion |
0.405038 | P01871 | IGHM | Immunoglobulin heavy constant mu; Constant region of immunoglobulin heavy chains |
0.411452 | P04278 | SHBG | Sex hormone-binding globulin; Androgen transport protein; regulates clearance rate of steroid hormones |
0.415369 | Q15848 | ADIPOQ | Adiponectin; Adipokine that controls fat metabolism and insulin sensitivity, and anti-inflammatory activities |
