Table 3 Displays the results for the crude and adjusted (gender, country and gene included as covariates) regression for SNP rs1801131(A > C) and rs1801133(C > T) in the whole sample (LS-related cancer) across all genes including EPCAM and PMS2.
From: MTHFR C677T and A1298C polymorphism’s effect on risk of colorectal cancer in Lynch syndrome
Crude | Adjusted | |||||
|---|---|---|---|---|---|---|
Characteristic | CRC-free Total n (%) | LS cancer total n (%) | HR (95% CI) total n (%) | p-value Total n (%) | HR (95% CI) total n (%) | p-value total n (%) |
rs1801131(A > C) | ||||||
AA | 554 (44%) | 697 (56%) | 1.00 | 1.00 | ||
AC | 525 (47%) | 597 (53%) | 0.90 (0.79–1.02) | 0.090 | 0.89 (0.89–1.00) | 0.060 |
CC | 88 (40%) | 132 (60%) | 0.98 (0.79–1.21) | 0.800 | 0.85 (0.69–1.05) | 0.140 |
rs1801133(C > T) | ||||||
CC | 472 (46%) | 565 (54%) | 1.00 | 1.00 | ||
CT | 555 (45%) | 676 (55%) | 0.99 (0.87–1.13) | 0.900 | 1.04 (0.92–1.18) | 0.500 |
TT | 134 (43%) | 180 (57%) | 1.01 (0.83–1.23) | > 0.900 | 1.04 (0.86–1.26) | 0.700 |
