Table 5 Displays results from Cox Regression analysis using the genotype results for A1298C (rs1801131) from the LS CRC sample cohort divided by individual MMR genes adjusted for gender and country.
From: MTHFR C677T and A1298C polymorphism’s effect on risk of colorectal cancer in Lynch syndrome
Crude | Adjusted | ||||
|---|---|---|---|---|---|
Gene | GT | HR (95% CI) | p-value | HR (95% CI) | p-value |
MLH1 | AA | 1 | 1 | ||
MLH1 | AC | 0.93 (0.76–1.14) | 0.465 | 0.88 (0.71–1.09) | 0.236 |
MLH1 | CC | 0.74 (0.51–1.06) | 0.095 | 0.61 (0.42–0.89) | 0.011 |
MSH2 | AA | 1 | 1 | ||
MSH2 | AC | 0.76 (0.61–0.94) | 0.013 | 0.74 (0.58–0.93) | 0.010 |
MSH2 | CC | 0.99 (0.70–1.41) | 0.972 | 0.87 (0.60–1.25) | 0.446 |
MSH6 | AA | 1 | 1 | ||
MSH6 | AC | 1.01 (0.70–1.45) | 0.978 | 0.98 (0.67–1.44) | 0.915 |
MSH6 | CC | 1.10 (0.57–2.15) | 0.773 | 1.05 (0.52–2.10) | 0.894 |
