Table 6 Displays results from Cox Regression analysis using the genotype results for C677T (rs1801133) from the LS-related cancer sample cohort divided by individual MMR genes adjusted for gender and country.
From: MTHFR C677T and A1298C polymorphism’s effect on risk of colorectal cancer in Lynch syndrome
Crude | Adjusted | ||||
|---|---|---|---|---|---|
Gene | GT | HR (95%CI) | p-value | HR (95%CI) | p-value |
MLH1 | CC | 1 | 1 | ||
MLH1 | CT | 0.18 (0.95–1.47) | 0.135 | 01.20 (0.97–1.48) | 0.095 |
MLH1 | TT | 1.15 (0.82–1.60) | 0.414 | 1.19 (0.87–1.64) | 0.277 |
MSH2 | CC | 1 | 1 | ||
MSH2 | CT | 0.87 (0.69–1.09) | 0.232 | 0.89 (0.71–1.11) | 0.298 |
MSH2 | TT | 1.19 (0.84–1.70) | 0.328 | 1.19 (0.85–1.67) | 0.314 |
MSH6 | CC | 1 | 1 | ||
MSH6 | CT | 0.92 (0.62–1.35) | 0.656 | 0.91 (0.62–1.33) | 0.624 |
MSH6 | TT | 0.69 (0.37–1.30) | 0.251 | 0.74 (0.40–1.38) | 0.350 |
