Table 1 Baseline information.

From: Safety comparisons among monoamine oxidase inhibitors against Parkinson’s disease using FDA adverse event reporting system

 

Selegiline

Rasagiline

Safinamide

Age in years (mean ± SD (n))

67.8 ± 12.7 (2667)

70.0 ± 10.7 (7209)

71.4 ± 9.8 (713)

Number of combination drugsa (mean ± SD)

8.5 ± 6.2

7.5 ± 5.6

7.8 ± 4.9

Monotherapyb (n, %)

34 (0.8%)

883 (8.3%)

57 (5.6%)

Female (n, %)

1517 (42.6%)

3998 (40.5%)

415 (44.3%)

Area (n, %)

   

 Northern America

1523 (45.2%)

6082 (59.6%)

377 (40.4%)

 Western Europe

201 (6.0%)

1497 (14.7%)

251 (26.9%)

 Eastern Asia

991 (29.4%)

708 (6.9%)

29 (3.1%)

 Northern Europe

310 (9.2%)

799 (7.8%)

62 (6.6%)

 Southern Europe

231 (6.9%)

439 (4.3%)

197 (21.1%)

 Eastern Europe

23 (0.7%)

169 (1.7%)

0 (0.0%)

 South America

42 (1.2%)

94 (0.9%)

16 (1.7%)

 Western Asia

4 (0.1%)

130 (1.3%)

0 (0.0%)

 Central America

8 (0.2%)

110 (1.1%)

0 (0.0%)

 Australia and New Zealand

22 (0.7%)

90 (0.9%)

1 (0.1%)

 Southern Asia

5 (0.1%)

40 (0.4%)

1 (0.1%)

 South-eastern Asia

11 (0.3%)

19 (0.2%)

0 (0.0%)

 Southern Africa

0 (0.0%)

19 (0.2%)

0 (0.0%)

 Caribbean

0 (0.0%)

5 (0.0%)

0 (0.0%)

 Northern Africa

0 (0.0%)

1 (0.0%)

0 (0.0%)

 Micronesia

0 (0.0%)

1 (0.0%)

0 (0.0%)

  1. In this table, unreported data were excluded from the calculation of both the count (n) and the percentage (%).
  2. aThe number of combination drugs was counted when other drugs were reported for the same primary ID.
  3. bMonotherapy is counted when no other drugs are reported for one primary ID.