Figure 2

Lipid species differentially expressed in > 2 L compared to 1 L patients. (A) Volcano plot reporting overexpressed lipids (in red), downregulated lipids (12, in blue), and nonsignificant lipids (in gray) in > 2 L vs. 1 L. Lipids overexpressed had a fold change > 1.2 and p value < 0.05, whereas dowregulated lipids had a fold change < 0.8 and p value < 0.05. (B) Heatmap of the 68 differentially expressed lipids. In the first row, red squares indicate patients belonging to the 1 L cohort, whereas green squares indicate patients belonging to the > 2 L cohort.