Figure 1
From: A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration
Schematic overview of animal experiments and detection workflow. (a) Graphic illustration of the workflow to acquire mouse plasma and brain tissue. The ICR mice were orally administrated 10 and 100 mg/kg Tyr-[13C5,15N]Pro, and then the plasma and brain tissue were collected at 0, 15, 30, 60, and 120 min. (b) Flow chart clarifying the plasma and brain tissue processing protocol. Plasma and brain tissue were applied to a solid phase extraction, reacted with APDS, and then analyzed by LC-qTOF/MS. APDS, 3-aminopyridyl-N-hydroxysuccinimidyl carbamate; LC-qTOF/MS, liquid chromatography-quadrupole time-of-flight/mass spectroscopy.
