Table 1 Pharmacokinetic parameters of Tyr-[13C5,15N]Pro in the plasma after oral administration to ICR mice at 10 and 100 mg/kg.

From: A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration

Parameter

Dose (mg/kg)

10

100

Cmax (pmol/mL-plasma)

49 ± 21

502 ± 167

tmax (min)

15

15

t1/2 (min)

12

8

AUC0–120 min (pmol·min/mL-plasma)

1331 ± 267

10,424 ± 4066

  1. Cmax maximum plasma concentration, AUC0–120 min area under the plasma concentration, tmax time to reach peak plasma concentration, t1/2 elimination half-life.
  2. Each value is expressed as mean ± SEM (n = 3–5).
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