Figure 17
Exploring the critical fraction of uninfected cells, \(T^{*}/N_\text {cells}\). (A) MFM time courses for the fraction of uninfected (black) and infectious (red) cells, for an infection initiated with 10 infectious virions under antiviral therapy reducing the virus entry rate, \(\beta \rightarrow (1-\varepsilon )\beta\), at efficacy \(\varepsilon = 0.81\), which yields an establishment probability (\({\mathcal {P}}_{V \rightarrow \, \text {Establishment}}=48\%\)) that is \(\sim\)50% of its value without antivirals23. The point \((t,T^{*}/N_\text {cells})\) is represented by a triangle; the time when \(T = T^{*}\) by a dashed line; and \(T=T(\infty )\) by an \(\times\) on the right vertical axis. The parameters are provided in Methods, but notably \(n_I=1\). (B,C) The reproductive number, R(t), as a function of the fraction of cells that remain uninfected, T(t), over the course of an infection (time is implicit), based on Eq. (48) when either \(R_0 = 2.2\) and \(T^{*}/N_\text {cells}\) is varied (B); or \(T^{*}/N_\text {cells} = 0.4\) and \(R_0\) is varied (C). The start of the infection is represented by a circle; the critical point where \(T=T^{*}\) and \(R = 1\) by a triangle; and the end of the infection where \(T=T(\infty )\) as given by Eq. (42) by an \(\times\).
