Figure 4
Effect of different antivirals on the probability of infection establishment. The establishment probability given an infection initiated with only one infectious virion as a function of efficacy (\(\varepsilon\)) for antivirals acting either to reduce the virus entry rate, \(\beta \rightarrow (1-\varepsilon )\beta\), the virus production rate, \(p \rightarrow (1-\varepsilon )p\), or the probability of a successful cell infection post virus entry, \(\gamma \rightarrow (1-\varepsilon )\gamma\). The line labelled \(\textcircled {0}\) indicates a value of lower efficacy (\(\varepsilon = 0.8\)), at line \(\textcircled {1}\) the establishment probability goes to zero (\(R_0=1\)) for an antiviral reducing p or \(\gamma\) (\(\varepsilon \approx 0.87\)), and at \(\textcircled {2}\) it goes to zero for an antiviral reducing \(\beta\) (\(\varepsilon \approx 0.92\)). The infection parameters are from Czuppon et al.23 (see Methods).
