Figure 7 | Scientific Reports

Figure 7

From: The effect of random virus failure following cell entry on infection outcome and the success of antiviral therapy

Figure 7

Effect of the susceptible cell population size on extinction and establishment. The frequency and complementary cumulative frequency of the fraction or number of cells consumed by the infection out of \(N_\text {cells}\), as the latter is varied, while \(\beta N_\text {cells}\), and therefore also the establishment probability and \(T^{*}/N_\text {cells}\), are fixed; (A) \(N_\text {cells} = {4 \times 10^3}\text {cells}\); (B) \({4 \times 10^5}\text {cells}\) or (C) \({4 \times 10^7}\text {cells}\). The frequency distribution in (A) is shown in (B) in grey, and that in (B) is shown in (C) in grey. As in Fig. 6(C), the efficacy (\(\varepsilon\)) of an antiviral reducing the virus production rate, \(p\rightarrow (1-\varepsilon )p\), was such that \(T^{*}/N_\text {cells} = 0.85\). Everything else is generated, computed, and represented visually as described in the caption of Fig. 5.

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