Figure 8
Effect of the susceptible cell population size on cells consumed by infection. The 95% bounds about the median (Eq. (40)) for the fraction and/or number of cells consumed by established infections, as a function of \(T^{*}/N_\text {cells}\), for different susceptible cell population sizes (\(N_\text {cells}\)) while holding \(\beta N_\text {cells}\) fixed. The 95% bounds are based on \(10^6\) SM simulations of which no less than about 40,000 were established infections (\({\mathcal {P}}_{V \rightarrow \, \text {Establishment}}\)=4% at \(T^{*}/N_\text {cells}=0.85\)). Here, \(T^{*}/N_\text {cells}=[c/(\beta N_\text {cells}/s)]/[\gamma p\tau _I-1]\) is increased by increasing the efficacy of an antiviral reducing the virus production rate, \(p\rightarrow (1-\varepsilon )p\).
