Figure 4

Lipid metabolism gene module deconvolution. (A) Heatmap showing the lipid metabolism module genes in the five cell types. (B) Top GOs enriched in AS genes. All 3 GO terms were based on Biological Processes (BP). (C) Top GOs enriched in MG genes. Fatty acid metabolic process and Regulation of cholesterol metabolic process were based on BP, while PPAR signaling pathway was based on WikiPathways. (D) Top GOs enriched in OG genes based on BP. (E) Correlation network of selected module genes from AS, MG and OG. (F) Dot plot showing gene fold changes of old versus young animals from our deconvoluted data, Ximerakis et al.¹², Allen et al.¹³, and Lee et al.¹⁴. AS genes are denoted in dark blue, MG genes in pink, and OG genes in gold.