Figure 5
From: The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains
Degenerative phenotypes of Def8 downregulation in the nervous system of Drosophila. (a) Lifespan, as measured by the percentage of control flies (blue line) and mutant Def8 flies (red line) alive over time (n = 100 flies). (b) Motor performance as measured by climbing activity on control flies (blue line) and mutant Def8 flies (red line) over time (n = 15 flies, n = 10). (c) Eye morphology in Def8-deficient models. Stereomicroscope images of external eye structure from flies downregulating Def8 and their controls under the regulation of the eye-specific driver GMR-Gal4. White arrows indicate altered morphology. ****p < 0.0001, **p < 0.01.
