Table 2 Metabolites associated with orthostatic blood pressure responses.
From: The relationships between the plasma metabolome and orthostatic blood pressure responses
Chemical name | Super pathway | Sub-pathway | β coff. | 95% CI | P value | ||
|---|---|---|---|---|---|---|---|
Lower limit | Upper limit | ||||||
1 | Behenoyl Dihydrosphingomyelin | Lipid | Dihydrosphingomyelins | − 0.94 | − 1.26 | − 0.61 | 1.92 × 10–8 |
2 | Aspartate | Amino acid | Alanine and Aspartate metabolism | − 0.87 | − 1.21 | − 0.54 | 3.74 × 10–7 |
3 | Creatine | Amino acid | Creatine metabolism | − 0.86 | − 1.21 | − 0.51 | 1.22 × 10–6 |
4 | Sphingomyelin | Lipid | Dihydrosphingomyelins | − 0.79 | − 1.12 | − 0.47 | 1.93 × 10–6 |
5 | Sphingosine | Lipid | Sphingosines | − 0.78 | − 1.10 | − 0.45 | 2.51 × 10–6 |
6 | Metabolonic Lactone sulfate | Partially characterized molecule | Partially characterized molecule | − 0.80 | − 1.13 | − 0.46 | 2.84 × 10–6 |
7 | Cysteine s-sulfate | Amino Acid | Methionine, Cysteine, SAM and Taurine metabolism | − 0.79 | − 1.12 | − 0.46 | 3.26 × 10–6 |
8 | Carotene Diol | Cofactors and vitamins | Vitamin A metabolism | 0.78 | 0.45 | 1.11 | 3.77 × 10–6 |
9 | Sphingadienine | Lipid | Sphingolipid synthesis | − 0.73 | − 1.05 | − 0.41 | 8.69 × 10–6 |
10 | Asparagine | Amino acid | Alanine and Aspartate metabolism | 0.73 | 0.40 | 1.05 | 1.22 × 10–5 |
11 | Glutamine | Amino acid | Glutamate metabolism | 0.72 | 0.40 | 1.05 | 1.34 × 10–5 |
12 | Bilirubin (E,Z or Z,E) | Cofactors and vitamins | Hemoglobin and Porphyrin metabolism | 0.72 | 0.39 | 1.05 | 1.65 × 10–5 |
13 | Bilirubin (Z,Z) | Cofactors and vitamins | Hemoglobin and Porphyrin metabolism | 0.72 | 0.39 | 1.05 | 1.69 × 10–5 |
14 | Sphingomyelin) | Lipid | Dihydrosphingomyelins | − 0.71 | − 1.04 | − 0.38 | 2.2 × 10–5 |
15 | 1-stearoyl-2-oleoyl-GPE | Lipid | Phosphatidylethanolamine (PE) | − 0.71 | − 1.03 | − 0.38 | 2.22 × 10–5 |
16 | Glucuronide of Piperine metabolite | Xenobiotics | Food component/Plant | − 0.71 | − 1.04 | − 0.38 | 2.53 × 10–5 |
17 | Glycoursodeoxycholic acid sulfate | Lipid | Secondary Bile Acid metabolism | − 0.71 | − 1.05 | − 0.37 | 3.78 × 10–5 |
18 | Dihomo-Linoleoylcarnitine | Lipid | Fatty acid metabolism (Acyl Carnitine, Polyunsaturated) | 0.69 | 0.36 | 1.02 | 4.2 × 10–5 |
19 | 1-Myristoyl-2-Arachidonoyl-GPC | Lipid | Phosphatidylcholine (PC) | − 0.69 | − 1.02 | − 0.36 | 4.28 × 10–5 |
20 | Glutamine degradant | Partially characterized molecule | Partially characterized molecule | 0.82 | 0.42 | 1.21 | 4.51 × 10–5 |
21 | Phenylacetate | Amino acid | Phenylalanine metabolism | 0.68 | 0.35 | 1.00 | 4.96 × 10–5 |
22 | 2-Naphthol Sulfate | Xenobiotics | Chemical | − 0.67 | − 0.99 | − 0.34 | 5.39 × 10–5 |
