Table 3 Examples of clinical mixed strain infections with disentangled the drug resistance mutations established for each strain using our GMM.
From: Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis
ID | Drug resistance (DR) profile | Strains Major; minor | Major prop.* | Minor prop.* | Major strain DR mutations | Minor strain DR mutations |
|---|---|---|---|---|---|---|
ERR4796347 (India) | Fluoroquinolones, ethionamide, ethambutol, streptomycin, rifampicin, isoniazid, pyrazinamide | L4.3.3; L2.2.1; | (0.64) [0.61] | (0.36) [0.39] | Ala90Val-gyrA Ser450Leu-rpoB n.514A>C-rrs c.-15C>T-fabG1 Ser315Thr-katG Thr160Ala-pncA Thr100Ile-pncA Met306Ile-embB | |
ERR4829977 (Pakistan) | Bedaquiline, clofazimine, ethionamide, ethambutol, isoniazid, rifampicin, streptomycin, | L3; L2.2.1.1 | (0.88) [0.79] | (0.12) [0.21] | p.Ile67fs-mmpR5 p.His445Asn-rpoB | p.Lys88Arg-rpsL c.-15C>T-fabG1 p.Gly406Asp-embB |
ERR4797884 (India) | Aminoglycosides, capreomycin, ethambutol, ethionamide, fluoroquinolones, isoniazid, kanamycin, linezolid, moxifloxacin, PAS, pyrazinamide, rifampicin, streptomycin | L3.1.2.1; L2.2.1 | (0.61) [0.55] | (0.39) [0.45] | Ser315Thr katG Glu170* gid | Asp94Gly gyrA Ser450Leu rpoB Lys43Arg rpsL Cys154Arg rplC n.1484G>T rrs c.-8T>C fabG1 Ser315Thr katG Thr177Pro pncA c.-16C>T thyX Met306Val embB |
