Figure 5 | Scientific Reports

Figure 5

From: 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins

Figure 5

Effects of 9-oxo-ODA treatment on HPV oncoprotein expression and downstream CDK1 and CDK2 expression. 9-oxo-ODAs suppress HPV oncoproteins, including (a) HPV16-E6, (b) HPV16-E7, (c) HPV18-E6, and (d) HPV18-E7 in a concentration-dependent manner. (e) siRNA-mediated knockdown of E6 reduces mRNA expression of E6, E7, CDK1, and CDK2. (f) siRNA-mediated knockdown of CDK1 does not affect mRNA expression of E6 and E7. (g) siRNA-mediated knockdown of CDK2 does not affect mRNA expression of E6 and E7.

Back to article page