Figure 6 | Scientific Reports

Figure 6

From: 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins

Figure 6

Antitumor effects of 9-oxo-ODAs on HeLa cells ex vivo and in vivo. (a) Schematic diagram of tissue collection from cervical cancer clinical specimens and ex vivo assay. (b) Representative immunohistochemistry images of CDK1, CDK2, and cleaved-caspase 3 in cervical cancer specimens treated with 9-oxo-ODAs or CDDP. (c-e) Positive rates of immunohistochemical staining for (c) CDK1, (d) cleaved-caspase 3, and (e) CDK2 (n = 9). Cutoff values were set for each and evaluated using QuPath. Due to missing data, n = 6 for CDDP 50 μM. (f) For in vivo analysis, HeLa-ip4 cells were inoculated into the pelvic cavity of mice followed by treatment with 9-oxo-ODAs or vehicle. (g) Comparison of tumor length diameter in 9-oxo-ODAs and vehicle groups.

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