Figure 1
From: Use of pediatric thymus to humanize mice for HIV-1 mucosal transmission
Human CD45+ cells detected in the peripheral blood of mice. (A–D) The percentage of hCD45+ cells in the peripheral blood are shown over time for (A) Leg PedThy produced with irradiation (●), with busulfan (■), no myeloablation (▲) or with busulfan and anti-CD2 antibodies (▼); (B) Renal PedThy; (C) HSC; and (D) BLT mice described in Table 1. Once reconstitution was reached, animals were challenged with HIV-1 and flow cytometry was no longer performed. (E) The percentage of hCD45+ cells in the peripheral blood at week 14–16 for each animal is shown and compared. * denotes p values ≤ 0.05; ns denotes p > 0.05. Each symbol denotes a separate animal.
