Figure 4
From: Use of pediatric thymus to humanize mice for HIV-1 mucosal transmission
Human CD3-CD19- cells detected in the peripheral blood of mice. (A–D) The percentage of hCD3-CD19- cells in the peripheral hCD45+ cell population are shown over time for (A) Leg PedThy, (B) Renal PedThy, (C) HSC, and (D) BLT mice described in Table 1. (E–F) The correlation of the percentages of hCD3-CD19- cells with (E) hCD45+ cells or (F) hCD3+ cells are shown for the last tested time point for the Leg PedThy, Renal PedThy, and BLT mice. Pearson correlation coefficients and 2-tailed p values are shown. Each symbol denotes a separate animal. Once reconstitution was reached, animals were challenged with HIV-1 and flow cytometry was no longer performed.
