Figure 2 | Scientific Reports

Figure 2

From: Human peritoneal tight junction, transporter and channel expression in health and kidney failure, and associated solute transport

Figure 2The alternative text for this image may have been generated using AI.

Tight junction protein abundance in children with normal kidney function, children with chronic kidney disease (CKD5) and on peritoneal dialysis (PD). Abundance of sealing claudins (CLDN1, CLDN3, CLND5), pore-forming claudins (CLDN2, CLDN4, CLDN15) and ZO-1, OCL and TriC in the mesothelial (A) and in the arteriolar area (B). CKD5 patients showed a higher abundance of peritoneal mesothelial claudin-2 and arteriolar claudin-3 than in controls. PD patient samples had highest mesothelial and arteriolar claudin-1 and mesothelial claudin-2 abundance, while mesothelial and arteriolar claudin-3 were lowest. Data are presented as median (IQR). One-way ANOVA with Holm-Sidak multiple comparison post-test or Kruskal–Wallis test with Dunn’s multiple comparison post-test were used, accordingly.

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