Table 5 Candidate drugs targeting genes with AD.
From: Copper metabolism-related Genes in entorhinal cortex for Alzheimer's disease
Drug | Gene | Interaction score | Clinical application |
|---|---|---|---|
SUCRALFATE | FGF2 | 5.89 | Approved |
REBAMIPIDE | FGF2 | 1.96 | Approved, investigational |
FAMOTIDINE | FGF2 | 1.47 | Approved |
ABT-510 | FGF2 | 1.47 | Investigational |
PYRAZOLE | FGF2 | 1.47 | Experimental |
THYROTROPIN | FGF2 | 1.18 | Investigational |
SQUALAMINE | FGF2 | 0.74 | Investigational |
QUIZARTINIB | FGF2 | 0.65 | Approved, investigational |
FP-1039 | FGF2 | 0.59 | Unsearchable |
PHENYLEPHRINE | FGF2 | 0.42 | Approved |
HYDROGEN PEROXIDE | PTPRC | 10.3 | Approved, vet approved |
CHEMBL204543 | PTPRC | 5.15 | Unsearchable |
APAMISTAMAB IODINE I-131 | PTPRC | 5.15 | Investigational |
ALENDRONIC ACID | PTPRC | 1.29 | Approved |
ADALIMUMAB | PTPRC | 0.91 | Approved, experimental |
ETANERCEPT | PTPRC | 0.81 | Approved, investigational |
INFLIXIMAB | PTPRC | 0.77 | Approved |
EPOETIN BETA | PTPRC | 0.74 | Approved |
ESTRADIOL | PTPRC | 0.34 | Approved, investigational, vet approved |
PREDNISONE | PTPRC | 0.32 | Approved, vet approved |
HYALURONAN | CD44 | 6.87 | Approved, vet approved |
GENTAMICIN | CD44 | 1.96 | Approved, vet approved |
PROGESTERONE | CD44 | 0.62 | Approved, vet approved |
ASK-8007 | SPP1 | 10.3 | unsearchable |
CALCITONIN | SPP1 | 3.43 | Approved, investigational |
GENTAMICIN | SPP1 | 0.98 | Approved, vet approved |
ALTEPLASE | SPP1 | 1.08 | Approved, investigational |
TACROLIMUS | SPP1 | 0.61 | Approved, investigational |
WORTMANNIN | SPP1 | 0.74 | Experimental |
