Figure 9 | Scientific Reports

Figure 9

From: Low-frequency magnetic fields potentiate plasma-modified magneto-electric nanoparticle drug loading for anticancer activity in vitro and in vivo

Figure 9

Schematic illustration of hypothesized anti-cancer drug release using MENs in the vicinity of cancer cells. This physical phenomenon is caused by electric field interactions (i) between MENs and drugs and (ii) between drug-loaded MENs and cells. The electric properties of the membrane enable MENs to differentiate between cancer cells and normal cells, as cancer cells exhibit a markedly lower threshold field for electroporation. By utilizing the high-specificity nano-electroporation effect, DOX-loaded MENs can infiltrate tumor cells when they come in proximity to the cell membrane surface. In contrast, normal cells remain intact due to a significantly higher nano-electroporation threshold field.

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