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Figure 1

From: Establishment of a novel indicator of pyroptosis regulated gene transcription level and its application in pan-cancer

Figure 1

Establishment of PPI and the clinical relevance of pyroptosis. (a) Protein–protein interaction network of positive regulator genes (left part with red circles) and negative regulator genes (right part with green circles). (b) Ratio of expression of PRGs in tumor tissue to normal tissue after log 2 transformation. (c) Heatmap showing the mutation frequencies of PRGs in different cancer types. (d) Histogram showing the frequencies of somatic copy number alterations for PRGs in different cancer types. (e) Heatmap showing the differential methylation of PRGs in different cancer types. (f) Survival relevance of expression levels of PRGs utilizing log-rank test (left part) and cox regression (right part).

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