Figure 5
Relation between pyroptosis and molecular features in cancers. (a) Landscape of TMB in pan-cancer. Results were presented after log10 transformation. Numeric characters in the upper figure indicated the numbers of the cases. Relation between PPI and tumor characteristics in various tumors types were established in radar maps (b–f). Tumor stemness were measured based on mRNA expression (RNAss, b) and DNA methylation (DNAss, c). Genome instability were evaluated by homologous recombination deficiency (HRD, d), microsatellite instability (MSI, e), tumor mutation burden (TMB, f). (g) Correlation between PPI and mRNA expression of acknowledged immune checkpoints in different tumor. The upper triangle of each tile demonstrates the p value, the lower triangle indicates coefficient applying Pearson correlation test. *p < 0.05, **p < 0.01, ***p < 0.001.
