Figure 4
From: miR-199a and miR-199b facilitate diffuse gastric cancer progression by targeting Frizzled-6
miR-199a and miR-199b are markers of poor prognosis in patients with DGC. (A) In situ hybridization of miR-199a or miR-199b in tissue microarrays of tumors from patients with DGC. Representative images of low/high miR-199a and miR-199b staining are presented. Original magnification × 40 (left) and × 400 (right). (B) Kaplan–Meier plots showing the overall survival (top) and disease-free survival rates (bottom) of patients with DGC. Patients were divided into two groups (miR-199a/b_high and miR-199a/b_low) based on their miR-199a (left) or miR-199b (right) expression levels. P, log-rank test. (C) In situ hybridization of miR-199a and miR-199b in tumor tissues from patients with DGC (n = 295) and intestinal GC (n = 112). Proportions of patients with high or low miR-199a/b expression levels are presented. P, Fisher’s exact test.
