Table 1 System suitability parameters for the HPLC–DAD determination of MLN and NHCa.

From: White targeted chromatographic screening method of Molnupiravir and its metabolite with degradation kinetics characterization and in-silico toxicity

Parameters

MLN

NHC

tR ± SD (min)b

3.7 min ± 0.01

2.4 min ± 0.01

Capacity factor (k')

3.83

3.19

Selectivity (α)

1.2

 

Theoretical plates (N)

13,467

10,085

Resolution (Rs)c

7.5

 

Tailing factor (Tf)

1.07

1.11

  1. aSystem suitability recommendations: k' (1–10), N > 2000, α > 1, Rs > 2 and Tf (0.8–1.2)20.
  2. bAverage tR ± SD of three determinations.
  3. cResolution between the drug and the DP1.
Back to article page