Table 5 Determination of MLN in Molnupiravir-Eva Pharma® capsules and spiked dosage form samples by the proposed HPLC–DAD method.

From: White targeted chromatographic screening method of Molnupiravir and its metabolite with degradation kinetics characterization and in-silico toxicity

Pharmaceutical formulation

HPLC–DAD

Molnupiravir-Eva Pharma® capsules (each pill containing 200 mg MLN)

%Found ± SDa

Spiking with the pure standard

  

Claimed (μg/ mL)

standard added (μg/ mL)

standard found (μg/ mL)

%Recovery of the standard addedb

(μg/ mL)

 

MLN 100.05 ± 0.23

50

2

10

20

Mean ± SD

2.03

9.96

20.41

101.5

99.6

102.0

101.03 ± 1.25

  1. aAverage of five determinations.
  2. bAverage of three determinations.
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