Table 1 Demographic data.

From: Endotoxin removal therapy with Polymyxin B immobilized fiber column: a single center experience from EUPHAS2 registry

Characteristic

Entire Cohort N = 61

Pre-flowchart N = 27

Post-flowchart N = 34

p value1

Age (years), median (IQR)

70 (34,89)

72 (66, 78)

68 (61, 74)

0.11

Gender, n(%)

0.8

 Male

42 (69)

19 (70)

23 (68)

 

 Female

19 (31)

8 (30)

11 (32)

 

 BMI (kg/m2), median (IQR)

24.3 (22.7, 27.8)

24.3 (22.7, 27.8)

25.8 (24.2, 29.2)

0.2

Type of suspected proven infection, n(%)

0.3

 Wound infection

6 (10)

3 (11)

3 (8.8)

 

 Primary peritonitis:

8 (13)

2 (7.4)

6 (18)

 

 Secondary peritonitis

22 (36)

13 (48)

9 (26)

 

 Community-acquired pneumonia

18 (29)

5 (19)

13 (38)

 

 Surgical urinary tract infection

4 (7)

2 (7.4)

2 (5.9)

 

 VAP

3 (5)

2 (7.4)

1 (2.9)

 

Main pathology, n(%)

0.2

 None other than infection

27 (44)

9 (33)

18 (53)

 

 ALI/ARDS

6 (10)

3 (11)

3 (8.8)

 

 Atrial fibrillation

2 (3)

1 (3.7)

1 (2.9)

 

 Cholecystitis

4 (6)

4 (15)

0 (0)

 

 Colitis

2 (3)

1 (3.7)

1 (2.9)

 

 Colon cancer

1 (2)

0 (0)

1 (2.9)

 

 Intrabdominal abscess

2 (3)

1 (3.7)

1 (2.9)

 

 Intrabdominal perforation

9 (15)

5 (19)

4 (12)

 

 Intestinal occlusion

3 (5)

0 (0)

3 (8.8)

 

 Pancreatitis

3 (5)

2 (7.4)

1 (2.9)

 

 Trauma

1 (2)

1 (3.7)

0 (0)

 

 Thoracic aorta dissection

1(2)

0 (0)

1 (2.9)

 

Comorbidities, n(%)

 

 Arrhythmia

6 (10)

4 (15)

2 (5.9)

0.4

 Cancer

7 (11)

3 (11)

4 (12)

> 0.9

 Diabetes

11 (18)

6 (22)

5 (15)

0.5

 Hypertension

29 (49)

12 (44)

17 (50)

0.7

 Hematologic malignancy

8 (13)

5 (19)

3 (8.8)

0.4

 Obesity

4 (7)

1 (3.7)

3 (8.8)

0.6

 Severe COPD

1 (2)

1 (3.7)

0 (0)

0.4

 No comorbidities

44 (72)

21 (78)

23 (68)

0.4

 Duration from hospital admission to septic shock (days)

1 (0, 36)

1 (0, 4)

2 (0, 10)

0.5

 Durationfrom ICU admission to septic shock (days)

0 (0, 30)

0.0 (0.0, 1.0)

0.0 (0.0, 1.0)

0.5

  1. 1Wilcoxon rank sum test; Pearson's Chi-squared test; Fisher’s exact test.
  2. ALI, acute lung injury; ARDS, acute respiratory distress syndrome; BMI, body mass index; COPD, chronic obstructive pulmonary disease; ICU, intensive care untit; PMX-HA, Polymyxin-B hemadsorption; VAP,ventilator-associated pneumonia.