Figure 4

The release of d-serine, l-serine and glutamine induced by H₂S and H₂S₂ in in vivo microdialysis. a to f. The release of d-serine (a and d), l-serine (b and e), glutamine (c and f) induced by H₂S (a to c) and by H₂S₂ (d to f) at the concentrations indicated in the figure in the wild-type rats (blue line) and TRPA1-KO (orange line). A baseline is defined as 100. (a) to (b) n = 7; (d) to (f) the wild-type n = 9, TRPA1-KO n = 8. All data are shown means ± SEM. Each peak value of the response was compared to the corresponding base line response observed at the start of the application of Na₂S or Na₂S₂. *p < 0.05, **p < 0.01, ^#p < 0.1 with Student’s t-test.