Figure 7
Construction and characterization of PTPRS. (a) Development of PTPRS in metaX training set and the predictive accuracy of PTPRS for survival. Validation of the PTPRS in metaX validation set and five external independent sets, including GSE71014, GSE37642, GSE106291, GSE12417 and GSE10358. (b, c) ROC-AUC value and C-index in different risk scoring systems. (d) Heatmap for infiltration of immune based on CIBERSORT, CIBERSORT-ABS, QUANTISEQ, MCPCOUNTER, XCELL, and EPIC algorithms among high-risk and low-risk group. (e–g) Functional and signaling pathway analysis of these differential genes in AML according to GO, Hallmarks, and KEGG pathway. *P < 0.05, **P < 0.01, ***P < 0.001.
