Table 5 Changes in voiding diary parameters after treatment between the groups at each study visit (Per-Protocol Set).

From: Recurrence after postoperative intravesical instillation therapy in Hunner type interstitial cystitis

 

Control group

HACS group

P†

Daytime frequency

 1mo

  n

54

45

 

  Mean change from baseline

− 5.08 ± 6.85

− 5.44 ± 5.75

0.757

  P*

 < 0.001

 < 0.001

 

 6mo

  n

45

34

 

  Mean change from baseline

− 3.07 ± 4.37

− 4.39 ± 7.60

0.751

  P*

 < 0.001

 < 0.001

 

 9mo

  n

32

32

 

  Mean change from baseline

− 3.22 ± 3.62

− 6.19 ± 6.53

0.029

  P*

 < 0.001

 < 0.001

 

 12mo

  n

32

31

 

  Mean change from baseline

− 2.22 ± 4.18

− 4.0 ± 5.64

0.159

  P*

0.005

 < 0.001

 

 18mo

  n

6

30

 

  Mean change from baseline

− 3.64 ± 3.62

− 4.57 ± 5.58

0.700

  P*

0.057

 < 0.001

 

 24mo

  n

3

23

 

  Mean change from baseline

− 0.55 ± 4.74

− 5.2 ± 6.28

NA

  P*

NA

 < 0.001

 

Nocturia

 1mo

  n

54

45

 

  Mean change from baseline

− 1.68 ± 2.39

− 1.17 ± 1.88

0.419

  P*

 < 0.001

 < 0.001

 

 6mo

  n

45

34

 

  Mean change from baseline

− 0.76 ± 1.63

− 0.75 ± 1.92

0.905

  P*

 < 0.001

0.030

 

 9mo

  n

32

32

 

  Mean change from baseline

− 0.89 ± 2.00

− 0.95 ± 2.01

0.768

  P*

0.009

0.012

 

 12mo

  n

32

31

 

  Mean change from baseline

− 0.85 ± 1.81

− 1.23 ± 1.97

0.398

  P*

0.012

0.002

 

 18mo

  n

6

30

 

  Mean change from baseline

− 1.53 ± 1.41

− 1.00 ± 2.44

0.615

  P*

0.050

0.033

 

 24mo

  n

3

22

 

  Mean change from baseline

0 ± 2.52

− 0.98 ± 2.18

NA

  P*

NA

0.047

 

Urgency episode

 1mo

  n

54

40

 

  Mean change from baseline

− 8.55 ± 11.35

− 6.91 ± 8.93

0.652

  P*

 < 0.001

 < 0.001

 

 6mo

  n

45

29

 

  Mean change from baseline

− 6.98 ± 9.49

− 4.6 ± 11.11

0.327

  P*

 < 0.001

0.034

 

 9mo

  n

32

27

 

  Mean change from baseline

− 7.28 ± 8.17

− 8.26 ± 9.76

0.675

  P*

 < 0.001

 < 0.001

 

 12mo

  n

32

26

 

  Mean change from baseline

− 5.59 ± 8.00

− 6.59 ± 9.16

0.328

  P*

 < 0.001

0.001

 

 18mo

  n

6

25

 

  Mean change from baseline

− 5.91 ± 9.28

− 6.69 ± 10.45

869

  P*

0.179

0.004

 

 24mo

  n

3

18

 

  Mean change from baseline

− 5.11 ± 11.08

− 6.83 ± 8.44

NA

  P*

NA

0.003

 
  1. HACS hyaluronic acid and chondroitin sulfate; NA not applicable (analysis was not performed because the number of control groups was less than five).
  2. *Compared to baseline, † between the two groups.
Back to article page