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Figure 1

From: Withaferin-A attenuates diabetes mellitus induced male reproductive dysfunction mediated by ERα in brain and testes of Swiss albino mice

Figure 1The alt text for this image may have been generated using AI.Figure 1The alt text for this image may have been generated using AI.

Effect of WA on DM induced reproductive dysfunction; (A) Body weight. (B) Paired testes weight. (C) Testicular volume. (D) Testis density. (E) Gonado-somatic index. (F) Graph showing fasting blood glucose levels weekly and (G) Area under curve (AUC), (calculated as a percentage with respect to normal control mice) over 8 weeks. Blood glucose was measured on days 0, 7, 14, 21, 28, 35, 42, 49, 56 and 63. (H) Oral glucose tolerance test including. (I) AUC after an encounter dose of D-glucose (2 g/kg) for the estimation of glucose tolerance in mice. (J) Intraperitoneal insulin (0.75 U/kg) tolerance test including its. (K) AUC after an encounter dose of insulin (0.75 U/kg) for the estimation of glucose clearance in mice. Values are presented as mean ± SD, (n = 6), significance of difference is considered as p ≤ 0.05 (*p ≤ 0.05, ***p ≤ 0.001) with respect to indicated groups. (*, **, and *** indicated the comparison between C and WA, STZ and STZ + WA; #, ##, and ### indicate significant difference from the diabetic (STZ) group at p < 0.05, p < 0.01 and < 0.001, respectively. [C, Control; STZ, Streptozotocin; WA, Withaferin-A; STZ + WA, Streptozotocin + Withaferin-A].

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