Figure 3 | Scientific Reports

Figure 3

From: Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis

Figure 3

Final population pharmacokinetic model (a) Final population pharmacokinetic model for i.v. fosfomycin with CVVHD. Total fosfomycin clearance (CL) is the sum of renal (CLRenal) and dialysis clearance (CLCVVHD). CLRenal increases with higher urinary creatinine clearance (CLCR). CLCVVHD is dependent on the hemodialyzer mass transfer-area coefficient (K0A), the blood flow rate (BFR) as well as the dialysis flow rate (DFR). The central volume compartment (VC) increases with time since first dose (TSFD). VP = peripheral compartment volume, Q = intercompartmental clearance. (b) Percentage of total fosfomycin clearance (CL) through CVVHD as a function of individual CLCR: the higher the creatinine clearance, the lower the proportion of dialysis clearance. CVVHD = continuous venovenous hemodialysis.

Back to article page