Figure 5 | Scientific Reports

Figure 5

From: Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis

Figure 5

Fosfomycin concentration–time profiles without and with preserved diuresis Exemplary fosfomycin concentration–time profiles of patients without (a–b) and with (c–d) preserved diuresis. Circles and dashed lines (white background) represent observed and individually predicted concentrations without CVVHD. Dots and solid lines (grey background) represent observed and individually predicted concentrations during CVVHD. Arrows indicate treatment with 5 g of i.v. fosfomycin. Preserved diuresis (c-d) resulted in considerably lower fosfomycin plasma concentrations. CVVHD = continuous venovenous hemodialysis.

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