Figure 6 | Scientific Reports

Figure 6

From: Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis

Figure 6

Model-based simulation of fosfomycin plasma concentration Model-based simulation of fosfomycin plasma concentration–time profiles over a period of 5 days after first dose for different dosing regimens (vertical panels) with varying creatinine clearances (horizontal panels) with CVVHD (blue line) and without CVVHD (black line). The dashed lines indicate current EUCAST and CLSI clinical breakpoints or ECOFFs for i.v. fosfomycin of 32, 64 and 128 µg/mL. CVVHD = continuous venovenous hemodialysis.

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