Figure 3

Hazard ratios with 95% confidence intervals of patients classified as having systemic progression relative to patients classified as having no progression for each lesion-level imaging biomarker investigated. Results are presented for: (a) ± 20% lesion-level response assessment threshold for progressing and responding lesions, (b) ± 30%, and (c) ± 40%. In all cases, SUVmean yielded the equal or highest C-Index. Vertical dotted line is plotted at a hazard ratio of 1 for easy visual comparison. All p values are less than 0.05, with the exception of volume for all investigated thresholds (after correcting for multiple testing using the Bonferroni method).