Table 2 A panel of putative metabolites with strong translational potential to be the marker of early response to lethal total body radiation (TBI).

From: Early to sustained impacts of lethal radiation on circulating miRNAs in a minipig model

HMDB ID

Name of putative metabolites

Biofunctions

Log2(fold change)

Early

Mid

Late

LR

Non-lipid metabolites/phosphates

HMDB0001202

dCMP

Marker of oxidative damage and metabolic disorder caused by radiation

1.13

1.17

1.16

1.01

HMDB0011155

1-1z-alkenyl-2-acylglycerophosphate

An intermediate of ether lipid metabolism

0.35

0.41

0.38

0.51

Phospholipids and glycerophospholipid

HMDB0009940

Phosphatidylinositol Phosphate(16:1/18:0)

Linked to cancer, cardiac atrophy, and nervous system disorder

0.20

0.24

0.18

0.18

HMDB0008951

Phophatidylethanolamine(16:1)

Linked to fatty acid metabolism and diabetes, often linked to radiation86

0.29

0.32

0.42

0.32

HMDB0007889

Phosphatidylcholine(36:4)

Linked to lipid metabolism

0.23

0.36

0.24

–

HMDB0009309

Phophatidylethanolamine(42:8)

Linked to lipid metabolism

0.34

0.33

0.33

–

HMDB0007881

Phosphatidylcholine(34:3)

Linked to carcinogenesis

0.39

0.35

0.26

–

HMDB0006588

Disialosyl galactosyl globoside

Linked to renal cell carcinoma

0.31

0.30

0.30

–

HMDB0007890

Phosphatidylcholine(36:5)

Linked to lipid metabolism

0.66

0.52

0.38

–

HMDB0012108

1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine

Linked to lipid metabolism

0.60

0.50

–

–

HMDB0007963

Phosphatidylcholine(15:1)

Linked to lipid metabolism

0.73

0.51

–

–

HMDB0007883

Phosphatidylcholine(34:4)

Linked to lipid metabolism

0.39

0.47

–

–

HMDB0009573

Phophatidylethanolamine(44:8)

Linked to fatty acid metabolism and diabetes, often linked to radiation86

0.71

0.55

–

–

HMDB0007894

Phosphatidylcholine(38:1)

Linked to lipid metabolism

0.35

0.38

–

–

HMDB0007940

Phosphatidylcholine(33:2)

Linked to lipid metabolism

0.71

0.69

–

–

HMDB0007874

Phosphatidylcholine(32:2)

Linked to lipid metabolism

0.43

0.45

–

–

HMDB0007937

Phosphatidylcholine(33:0)

Linked to lipid metabolism

0.38

0.43

–

–

  1. This putative metabolite panel met two selection criteria: (i) these putative metabolites are differentially expressed in sus scrofa from its pre-TBI baseline in at least one post-TBI phase; and (iii) in sus scrofa, these putative metabolites were consistently expressed in at least two consecutive time points starting from the Early post-TBI phase. The biofunctions, if not cited, were curated from https://hmdb.ca/metabolites. The putative list of metabolites were sorted into organic class of compounds, namely lipid and non-lipid metabolites, and all these spectral features were differentially expressed from the pre-TBI baseline with t-test p < 0.05.
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