Table 3 Evaluation of the robustness of the proposed spectrophotometric methods for the determination of ERD by various reagents.

From: Multiple green spectroscopic methods for erdosteine determination in bulk and dosage form with extensive greenness evaluation

 

Parameters

Mean rec. % ± SDa

RSD %b

Method I

KMnO4 volume ± 0.2 mL

100.41 ± 1.86

1.85

NaOH volume ± 0.2 mL

98.62 ± 1.43

1.45

Reaction time ± 5 min

98.31 ± 1.87

1.90

Wavelength ± 2 nm

98.23 ± 0.83

0.85

Method II

Ce4+ volume ± 0.1 mL

99.59 ± 0.83

0.83

H2SO4 volume ± 0.05 mL

98.96 ± 0.80

0.81

Reaction time ± 5 min

98.21 ± 0.77

0.78

Wavelength ± 2 nm

99.00 ± 0.13

0.13

Method III

Wavelength ± 2 nm

98.78 ± 1.20

1.22

Method IV

Acriflavine volume ± 0.2 mL

100.89 ± 1.20

1.19

Buffer volume ± 0.2 mL

100.25 ± 1.41

1.41

Buffer pH ± 2 units

100.46 ± 1.76

1.75

Reaction time ± 2 min

101.59 ± 0.68

0.67

Wavelength ± 2 nm

101.59 ± 0.24

0.24

  1. aMean percentage recovery for three determinations.
  2. b% relative standard deviation.
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