Figure 4 | Scientific Reports

Figure 4

From: Continuous therapy response references for BCR::ABL1 monitoring in pediatric chronic myeloid leukemia

Figure 4

Bi-exponential modeling for the comparison of BCR::ABL1 transcript levels and fusion gene numbers during TKI treatment over 5 years. (a) Comparison of RNA (blue) and DNA (orange) molecular response kinetics plotted over 96 months of therapy as bi-exponential graphs based on a population-based non-linear mixed effect model. (b) Difference of logarithmic transcript and fusion gene level (log10 RNA–log10 DNA) over 96 months adapted from the modeled bi-exponential kinetics for RNA- and DNA-based molecular response. (c) Slope α and slope β (d) of the RNA bi-exponential graph (blue) compared to the DNA bi-exponential graph (orange). ns not significant, **p < 0.01 (paired t-test).

Back to article page