Table 1 Roberts’ age-adjusted warfarin initiation protocol.

From: Chinese stroke patients with atrial fibrillation used Robert's age-adjusted warfarin loading protocol obtained good INR results within therapeutic range

Day

INR

Dose for age (mg)

 ≤ 50y

51–65 y

66–80 y

 > 80 y

1

 < 1.4

10

9

7.5

6

2 (16 h after 1st dose)

 ≤ 1.5

10

9

7.5

6

 ≥ 1.6

0.5

0.5

0.5

0.5

3 (16 h after 2nd dose)

 ≤ 1.7

10

9

7.5

6

1.8–2.3

5

4.5

4

3

2.4–2.7

4

3.5

3

2

2.8–3.1

3

2.5

2

1

3.2–3.3

2

2

1.5

1

3.4

1.5

1.5

1

1

3.5

1

1

1

0.5

3.6–4.0

0.5

0.5

0.5

0.5

 > 4.0

0

0

0

0

4 (16 h after 3rd dose)

 ≤ 1.5

10–15

9–14

7.5–11

6–9

1.6

8

7

6

5

1.7–1.8

7

6

5

4

1.9

6

5

4.5

3.5

2.0–2.6

5

4.5

4

3

2.7–3.0

4

3.5

3

2.5

3.1–3.5

3.5

3

2.5

2

3.6–4.0

3

2.5

2

1.5

4.1–4.5

omit next days’ dose, then

1–2

0.5–1.5

0.5–1.5

0.5–1

 > 4.5

withhold dose

  1. INR international normalized ratio.
  2. Patients routinely received warfarin doses at 8:00 Hrs each day during titration protocol. Blood samples for INR were obtained between 07:00 to 08:00 h the next morning.
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