Table 4 Association of anthropometric or MetS variables and all-cause or BC-specific mortality by luminal subtypes (A vs. B).

From: Central obesity, body mass index, metabolic syndrome and mortality in Mediterranean breast cancer patients

Variable

Luminal A

Luminal B

Deaths/N total cases

Deaths from all-causes

Deaths from breast cancer

Deaths/N total cases

Deaths from all-causes

Deaths from breast cancer

HR* (95% CI)

p**

HR (95% CI)

p**

HR* (95% CI)

p**

HR (95% CI)

p**

Body mass index, kg/m2

  

0.247

 

0.090

  

0.675

 

0.386

 < 25

11/103

1

 

1

 

19/117

1

 

1

 

 25–30

21/110

1.28 (0.61-2.69)

 

0.75 (0.23–2.49)

 

29/127

0.98 (0.52–1.87)

 

1.05 (0.47–2.36)

 

 ≥ 30

27/91

1.79 (0.87–3.67)

 

2.05 (0.78–5.36)

 

26/92

1.24 (0.64–2.40)

 

1.59 (0.71–3.56)

 

 Per 5.0 U

59/304

1.24 (0.97–1.58)

0.084

1.43 (1.02–2.00)

0.038

74/336

1.18 (0.93–1.49)

0.169

1.28 (0.97–1.68)

0.083

Waist circumference, cm

  

0.099

 

0.147

  

0.073

 

0.221

< 88

15/136

1

 

1

 

19/137

1

 

1

 

 ≥ 88

43/166

1.66 (0.89–3.10)

 

2.00 (0.79–5.09)

 

50/185

1.66 (0.94–2.95)

 

1.51 (0.77–2.97)

 

 Per 10 U

58/302

1.28 (1.05–1.55)

0.013

1.41 (1.07–1.86)

0.016

69/322

1.18 (1. 01–1.38)

0.034

1.22 (1.01–1.46)

0.036

Waist-to-hip ratio

  

0.058

 

0.318

  

0.104

 

0.301

 ≤ 0.85

9/103

1

 

1

 

15/108

1

 

1

 

 > 0.85

49/198

2.10 (0.97–4.52)

 

1.62 (0.60–4.39)

 

54/194

1.63 (0.89–3.00)

 

1.44 (0.71–2.91)

 

 Per 0.1 U

58/301

1.74 (1.28–2.39)

0.001

1.92 (1.27–2.90)

0.002

69/322

1.13 (0.86–1.48)

0.388

1.08 (0.77–1.53)

0.654

Metabolic syndrome (MetS)

  

0.002

 

0.023

  

0.885

 

0.890

 No

18/164

1

 

1

 

36/193

1

 

1

 

 Yes

25/58

2.84 (1.47–5.48)

 

2.81 (1.15–6.86)

 

19/60

1.04 (0.58–1.89)

 

1.05 (0.50–2.23)

 

MetS components

  

0.036

+

0.193

  

0.059

 

0.158

 None

0/37

    

4/44

1

 

1

 

 None+1–2

15/135

1

 

1

 

30/121

3.07 (1.07–8.81)

 

2.91 (0.85–9.90)

 

 ≥ 3

25/58

2.98 (1.52–5.88)

0.002

2.80 (1.14–6.88)

0.03

19/60

1.02 (0.56–1.86)

0.9

2.44 (0.66–9.04)

 
  1. *HR adjusted by terms of: age (≤ 40, 41–60, > 60), center (Pascale, Policlinico), Stage (I–IIA, IIB, IIIA–IIIC).
  2. **For the entire variable the p-value refers to Wald Test, for numerical variable z-Test p-value was reported. +model was not implemented due to absence of events in reference category.
  3. Significant results are shown in bold.
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