Table 2 Comparison of clinical and laboratory data of the collectives at baseline vs. D7 and between groups at D7.

From: Effect of restrictive cumulative fluid balance on 28-day survival in invasively ventilated patients with moderate to severe ARDS due to COVID-19

Variables

CFB negative trend (−)

CFB negative trend (−)

p

CFB positive trend (+)

CFB positive trend (+)

p

D0 (n = 89)

D7 (n = 89)

D0 (n = 82)

D7 (n = 82)

SOFA score, mean ± SD

6.1 ± 2.3

6.4 ± 2.4

0.919

5.9 ± 2.4

6.2 ± 2.7

0.681

Median (Q1–Q3)

6 (4–7)

6 (4–8)

 

5 (4–7)

6 (4–8)

 

Creatinine [mg/dL], mean ± SD

1.12 ± 0.71

1.80 ± 1.20

 < 0.001

1.4 ± 1.4

2.1 ± 1.6

 < 0.001

Median (Q1–Q3)

1 (0.75–1.25)

1.6 (0.9–2.7)

 

1 (0.8–1.6)

1.5 (0.9–3)

 

Mean arterial pressure, mean ± SD

83.5 ± 15

77.1 ± 15.1

0.026

81.6 ± 18.1

80.7 ± 12.5

0.257

Median (Q1–Q3)

81 (74–95)

77 (67–86)

 

80 (74–92.7)

79.5 (72–87)

 

Lactate [mmol/L], mean ± SD

1.94 ± 0.64

2.77 ± 3.8

 < 0.001

2.12 ± 0.93

2.46 ± 1.1

0.681

Median (Q1–Q3)

1.74 (1.52–2.3)

2.15 (1.7–2.9)

 

1.90 (1.56–2.43)

2.2 (1.9–2.5)

 

Hemoglobin [g/dL], mean ± SD

12.3 ± 1.87

11.16 ± 1.70

 < 0.001

12.2 ± 2.0

10.17 ± 1.80

 < 0.001

Median (Q1–Q3)

12.5 (11.4–13.5)

11 (10.1–12.4)

 

12 (11–13.7)

10.1 (8.6–11.8)

 

Comparison of D7 vs. D7

 SOFA score, mean ± SD

6.4 ± 2.4

 

6.2 ± 2.7

0.436

 Median (Q1–Q3)

6 (4–8)

 

6 (4–8)

 

 Creatinine [mg/dL], mean ± SD

1.80 ± 1.20

 

1.5 (0.9–3)

0.240

 Median (Q1–Q3)

1.6 (0.9–2.7)

 

1.5 (0.9–3

 

 Mean arterial pressure, mean ± SD

76.6 ± 15.0

 

81.5 ± 12.03

0.043

 Median (Q1–Q3)

77 (66.5–86)

 

80 (74–87)

 

 Lactate [mmol/L], mean ± SD

2.77 ± 3.8

 

2.46 ± 1.1

0.620

 Median (Q1–Q3)

2.15 (1.7–2.9)

 

2.2 (1.9–2.5)

 

 Hemoglobin [g/dL], mean ± SD

11.24 ± 1.65

 

10.12 ± 1.80

 < 0.001

 Median (Q1–Q3)

11 (10.1–12.4)

 

10.1 (8.6–11.8)

 

 Cumulative fluid balance trend [ml], mean ± SD

− 298 ± 612

 

1405 ± 930

 < 0.001

 Median (Q1–Q3)

− 279 (− 664 to 203)

 

1362 (619–3773)

 
  1. Values summarized as mean ± SD and median Q1/3 (first and third quartile).p-value was calculated by Wilcoxon signed rank test for the comparison between baseline and D7 continuous variables of each group. The comparison von D3 vs. D3 was mad with Mann–Whitney test.
  2. SOFA score: sequential organ failure assessment score, PaO2 partial pressure of oxygen in the arterial blood, PEEP positive end-expiratory pressure, p p-value (< 0.05 marked in bold).
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