Figure 2 | Scientific Reports

Figure 2

From: IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation

Figure 2

CD97 expression is crucial for IL-8-induced EMT in ICC cells. Wound healing assays (A,B) and transwell migration assays (C,D) were performed to evaluate the migration of QBC-939 and RBE cells expressing sh-CD97 or sh-NC after IL-8 or solvent treatment. The expression levels of the EMT-associated proteins E-cadherin, N-cadherin and vimentin in QBC-939 and RBE cells expressing sh-CD97 or sh-NC after IL-8 or solvent treatment were determined by WB (E,F). *P < 0.05, **P < 0.01, ***P < 0.001, #P > 0.05. sh, short hairpin; NC, negative control.

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