Table 1 Relationship of IL-8 and CD97 expression with clinicopathological factors.

From: IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation

Factor

Number

IL-8 expression (n,%)

P

CD97 expression (n,%)

P

Low

High

Low

High

Sex

 Female

61

17(27.9)

44(72.1)

0.448

17(27.9)

44(72.1)

0.840

 Male

64

22(34.4)

42(65.6)

 

16(25.0)

48(75.0)

 

 Age at diagnosis (years)

125

57.56 ± 10.19a

58.45 ± 10.71a

0.663

58.39 ± 10.51a

58.10 ± 10.58a

0.890

Histological differentiation

 Well

11

8(72.7)

3(27.3)

0.001*

7(63.6)

4(36.4)

0.007*

 Moderately

78

27(34.6)

51(65.4)

 

21(26.9)

57(73.1)

 

 Poorly

36

4(11.1)

32(88.9)

 

5(13.9)

31(86.1)

 

Lymph node metastasis

 Negative

81

31(38.3)

50(61.7)

0.026*

30(37.0)

51(63.0)

0.001*

 Positive

44

8(18.2)

36(81.8)

 

3(6.8)

41(93.2)

 

Vascular invasion

 Negative

91

36(39.6)

55(60.4)

0.001*

32(35.2)

59(64.8)

0.001*

 Positive

34

3(8.8)

31(91.2)

 

1(2.9)

33(97.1)

 

Nerve invasion

 Negative

79

27(34.2)

52(65.8)

0.425

19(24.1)

60(75.9)

0.529

 Positive

46

12(26.1)

34(73.9)

 

14(30.4)

32(69.6)

 

Tumor size

  < 3 cm

44

15(34.1)

29(65.9)

0.687

14(31.8)

30(68.2)

0.396

  > 3 cm

81

24(29.6)

57(70.4)

 

19(23.5)

62(76.5)

 

Tumor nodules

 Single

100

32(32.0)

68(68.0)

0.812

27(27.0)

73(73.0)

1.000

 Multiple

25

7(28.0)

18(72.0)

 

6(24.0)

19(76.0)

 

CD97 expression

 Low

33

24(72.7)

9(27.3)

0.001*

   

 High

92

15(16.3)

77(83.7)

    
  1. aPresented as the mean ± standard deviation.
  2. *P < 0.05.