Table 1 MR estimates of assessing the causal association between IBD and periodontitis.

From: Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization

Outcome

Exposure

Method

OR

95% CI

P-value

Periodontitis

IBD

Inverse variance weighted

1.003

0.977

1.030

0.808

Periodontitis

IBD

MR Egger

0.984

0.932

1.040

0.576

Periodontitis

IBD

Weighted median

0.989

0.944

1.037

0.660

Periodontitis

CD

Inverse variance weighted

1.023

1.000

1.047

0.051

Periodontitis

CD

MR Egger

1.008

0.956

1.064

0.766

Periodontitis

CD

Weighted median

1.009

0.973

1.047

0.628

Periodontitis

UC

Inverse variance weighted

0.988

0.958

1.019

0.448

Periodontitis

UC

MR Egger

0.956

0.876

1.043

0.313

Periodontitis

UC

Weighted median

0.969

0.926

1.014

0.180

IBD

Periodontitis

Inverse variance weighted

0.989

0.898

1.088

0.813

IBD

Periodontitis

MR Egger

1.027

0.919

1.148

0.660

IBD

Periodontitis

Weighted median

1.005

0.915

1.103

0.917

CD

Periodontitis

Inverse variance weighted

0.945

0.830

1.077

0.398

CD

Periodontitis

MR Egger

1.000

0.864

1.156

0.996

CD

Periodontitis

Weighted median

0.967

0.864

1.082

0.558

UC

Periodontitis

Inverse variance weighted

1.040

0.928

1.165

0.504

UC

Periodontitis

MR Egger

1.075

0.930

1.242

0.385

UC

Periodontitis

Weighted median

1.084

0.957

1.228

0.205

  1. IBD inflammatory bowel disease, CD Crohn’s disease, UC ulcerative colitis, MR Mendelian randomization, OR odds ratio, CI confidence interval, P: P value tests the null hypothesis of no association with exposure.
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